The Formulation of an Anti-Aging Serum With Liposomes Containing Durian (Durio zibethinus Murr.) Peel Extract
Corressponding author's email:
kevinton150691@gmail.comDOI:
https://doi.org/10.54644/jte.2025.1908Keywords:
Anti-aging, Durian peel extraction, Polyphenolic compounds, Liposome, Enhanced penetrationAbstract
Durian (Durio zibethinus Murr.) peel is considered a food byproduct, although it is a good source of bioactive compounds for anti-aging skincare products. In this research, a Vietnamese durian was collected, and its white peel was extracted by ethanol and hexane to utilize the bioactive compounds for green cosmetic development. The total flavonoid content and total phenolic content were 857.13 ± 80.91 µg QE/g dried peel and 6549.58 ± 884.32 µg GAE/g dried peel, respectively. Subsequently, this extract was encapsulated by a liposome nanocarrier by thin film hydration for deeper skin penetration, which was physically characterized by size and zeta potential. The size of plain liposome was 102.9 nm (PDI 0.210) along with the stable monodispersibility by zeta potential of -31.40 mV while the diameter of extract-loaded liposome was 250.0-280.0 nm with low zeta potential values. On the other hand, the stability of the extract-loaded liposome was also investigated. The result showed the extract-loaded liposome expanded its size after storing at 4oC, 25oC and 40 °C, at both PBS 7.4 and 5.5, within one-month storage. Finally, an anti-aging serum containing extract-loaded liposomes was formulated. Under an optical microscope, the emulsion showed a size of 10-50 µm, spherical, and monodisperse. However, the pH of the serum base and serum lipo 0.1% got an unstoppable increase at 4oC, 25oC and 40 °C within one-month storage. This information is necessary for the future contribution of durian byproducts as a rich source of bioactive compounds for green skincare products.
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